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Antibiotic prophylaxis in cardiac surgery
  1. Graeme MacLaren1,
  2. Siang Fei Yeoh2,
  3. Denis Spelman3
  1. 1
    Cardiothoracic Intensive Care Unit, National University Hospital, Singapore
  2. 2
    Department of Pharmacy, National University Hospital, Singapore
  3. 3
    Department of Infectious Diseases and Microbiology, The Alfred Hospital, Melbourne, Australia
  1. Graeme MacLaren, Cardiothoracic Intensive Care Unit, National University Hospital, Singapore; gmaclaren{at}iinet.net.au

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To the Editor: The recent study by Dhadwal et al1 has a number of weaknesses which merit discussion. The study appears to have been initiated by a “perceived increase in crude infection rates” but the organisms responsible for this increase were not presented. Unless there was a high incidence of infection with resistant organisms such as methicillin-resistant Staphylococcus aureus (MRSA) prior to study commencement, the routine use of vancomycin in a multi-drug …

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