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The authors’ reply:
  1. R Rubinshtein,
  2. T D Miller,
  3. P A Araoz
  1. Mayo Clinic, Rochester, Minnesota, USA
  1. Dr R Rubinshtein, Mayo Clinic, 200 First ST SW, MB 4-506, Rochester, MN 55905, USA; rubinshteinr{at}

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We thank Dr Heston for his interest in our paper.1 We are encouraged that Dr Heston found our results to have clinical significance and we agree with his conclusion that the positive predictive value in our paper was meaningful, especially given the low prevalence of …

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