Table 6 Predictors of non-response to cardiac resynchronisation therapy (patients with CRT and concurrent cardiac surgical procedure
excluded)
| Predictors | Responders (n = 66) | Non-responders (n = 15) | p Value | |
| Univariate | Multivariable | |||
| Congenital heart disease (%) | 80.3 | 46.7 | 0.018 | NS |
| Congenital complete AV block (%) | 15.2 | 13.3 | 1.000 | Not tested |
| Dilated cardiomyopathy (%) | 4.5 | 40 | <0.001 | 0.002 |
| Initial NYHA class (median) | 2.0 | 3.0 | <0.001 | 0.003 |
| Age at CRT (years), median | 18.1 | 11.2 | 0.447 | Not tested |
| Systemic right ventricle (%) | 28.8 | 20.0 | 0.749 | Not tested |
| Pacing before CRT (%) | 81.8 | 60.0 | 0.087 | Not tested |
| Initial SVEDD (z score), mean (SD) | +3.5 (2.7) | +6.3 (3.4) | 0.003 | NS |
| Initial SF (%), mean (SD) | 17.3 (9.9) | 12.9 (4.2) | 0.148 | Not tested |
| Initial EF/FAC (%), mean (SD) | 31.6 (14.5) | 22.5 (10.2) | 0.101 | Not tested |
| Initial SAVV regurgitation (grade), median | 1 | 2 | 0.682 | Not tested |
| Initial QRS duration (ms), median | 160 | 150 | 0.301 | Not tested |
| QRS shortening by CRT (ms), median | −40 | −30 | 0.357 | Not tested |
| Thoracotomy or mixed lead system (%) | 50.0 | 53.3 | 1.000 | Not tested |
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AV, atrioventricular; CRT, cardiac resynchronisation therapy; EF, ejection fraction; FAC, fractional area of change; NYHA, New York Heart Association; SAVV, systemic atrioventricular valve; SF, shortening fraction; SVEDD, systemic ventricular end-diastolic dimension.
