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Heart 95:1225-1229 doi:10.1136/hrt.2008.150631
  • Original article

Assessment of aspirin resistance varies on a temporal basis in patients with ischaemic heart disease

Table 5 Comparison of serum thromboxane B2 levels with resistance by OPA and non-response by PFA-100 resistance cohort (n = 172)
Resistant by AA aggregation Sensitive by AA aggregation Significance
TXB2 at visit 1 146.8 pg/ml 89.6 pg/ml p = 0.99
(11.0–334.8) (43.5–230.0)
n = 3 n = 169
TXB2 at visit 2 120.9 pg/ml 111.3 pg/ml p = 0.69
(28.3–219.3) (46.6–252.1)
n = 8 n = 164
Non-response by PFA-100 Sensitive by PFA-100 Significance
TXB2 at visit 1 84.2 pg/ml 92.8 pg/ml p = 0.30
(37.3–175.6) (43.5–231.3)
n = 38 n = 134
TXB2 at visit 2 194.6 pg/ml 92.9 pg/ml p = 0.02
(46.6–544.6) (46.4–201.1)
n = 35 n = 137
  • Results displayed as medians and interquartile ranges.

  • AA, arachidonic acid; PFA-100, platelet function analyser-100; TXB2, thromboxane B2.

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