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We thank Solbiati et al for their thoughtful comments on our paper.1 They wonder whether possible selection differences compared to two previous unblinded studies2,3 influenced our results. Certainly is it impossible to be certain that the characteristics of the patients in our study are exactly the same as those in similar studies but that was not the purpose of our research. It is true that the death rate observed in this study (4/34, 12%) was higher than expected …
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