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Heart 2009;95:1907-1912 doi:10.1136/hrt.2009.167759
  • Original article
  • Interventional cardiology

Optical coherence tomography evaluation of zotarolimus-eluting stents at 9-month follow-up: comparison with sirolimus-eluting stents

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  1. J-S Kim1,
  2. I-K Jang2,
  3. J-S Kim1,
  4. T H Kim1,
  5. M Takano3,
  6. T Kume4,
  7. N W Hur5,
  8. Y-G Ko1,
  9. D Choi1,
  10. M-K Hong1,
  11. Y Jang1
  1. 1
    Division of Cardiology, Yonsei Cardiovascular Centre, Yonsei University College of Medicine, Seoul, Korea
  2. 2
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
  3. 3
    Divison of Cardiology, Nippon Medical School, Tokyo, Japan
  4. 4
    Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
  5. 5
    Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea
  1. Correspondence to Dr Y Jang, Division of Cardiology, Yonsei Cardiovascular Centre, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, 120-752 Seoul, Korea; jangys1212{at}yuhs.ac
  • Accepted 26 May 2009
  • Published Online First 16 June 2009

Abstract

Objective: To evaluate the vascular response at 9 months after zotarolimus-eluting stent (ZES; Endeavor) implantation using optical coherence tomography (OCT). These findings were compared with those after implantation of a sirolimus-eluting stent (SES; Cypher Select).

Design: Cross-sectional observational study with prospective OCT registry.

Setting: Nine months after ZES or SES implantation.

Patients and methods: A total of 68 patients (32 ZES and 36 SES) underwent OCT at 9 months after stent implantation. The neointima hyperplasia (NIH) thickness inside each strut and percentage of NIH area at every 1 mm cross section were measured.

Main outcome measurement: The degree of neointimal coverage and the prevalence of malapposition at 9 months after ZES and SES implantation using OCT.

Results: The mean (SD) NIH thickness (251.2 (110.0) μm vs 85.5 (53.3) μm, p<0.001) and percentage of NIH area (27.9 (9.1)% vs 11.2 (7.1)%, p<0.001) were significantly greater in ZES than in SES. The prevalence of uncovered strut as well as malapposed strut was significantly lower in ZES than in SES (0.3% vs 12.3%, p<0.001 and 0.08% vs 2.6%, p<0.001). Thrombus was not observed in ZES (0.0% in ZES vs 27.8% in SES, p = 0.001).

Conclusions: Neointimal coverage in ZES was almost complete and malapposition was very rare at 9-months’ follow-up.

Footnotes

  • Funding This study was supported by a faculty research grant from the Department of Internal Medicine, Yonsei University College of Medicine, 2008 and by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea. (No A085012).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • See Editorial, p 1895

  • Ethics approval Ethics committee approval from Severance IRB.

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