Article Text
Abstract
Objective: To evaluate the vascular response at 9 months after zotarolimus-eluting stent (ZES; Endeavor) implantation using optical coherence tomography (OCT). These findings were compared with those after implantation of a sirolimus-eluting stent (SES; Cypher Select).
Design: Cross-sectional observational study with prospective OCT registry.
Setting: Nine months after ZES or SES implantation.
Patients and methods: A total of 68 patients (32 ZES and 36 SES) underwent OCT at 9 months after stent implantation. The neointima hyperplasia (NIH) thickness inside each strut and percentage of NIH area at every 1 mm cross section were measured.
Main outcome measurement: The degree of neointimal coverage and the prevalence of malapposition at 9 months after ZES and SES implantation using OCT.
Results: The mean (SD) NIH thickness (251.2 (110.0) μm vs 85.5 (53.3) μm, p<0.001) and percentage of NIH area (27.9 (9.1)% vs 11.2 (7.1)%, p<0.001) were significantly greater in ZES than in SES. The prevalence of uncovered strut as well as malapposed strut was significantly lower in ZES than in SES (0.3% vs 12.3%, p<0.001 and 0.08% vs 2.6%, p<0.001). Thrombus was not observed in ZES (0.0% in ZES vs 27.8% in SES, p = 0.001).
Conclusions: Neointimal coverage in ZES was almost complete and malapposition was very rare at 9-months’ follow-up.
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Footnotes
Funding This study was supported by a faculty research grant from the Department of Internal Medicine, Yonsei University College of Medicine, 2008 and by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea. (No A085012).
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
See Editorial, p 1895
Ethics approval Ethics committee approval from Severance IRB.