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Negative vascular remodelling after implantation of bioabsorbable magnesium alloy stents in porcine coronary arteries: a randomised comparison with bare-metal and sirolimus-eluting stents
  1. M Maeng1,2,
  2. L O Jensen3,
  3. E Falk1,2,
  4. H R Andersen1,2,
  5. L Thuesen1,2
  1. 1
    Department of Cardiology, Aarhus University Hospital, Skejby, Denmark
  2. 2
    Institute of Clinical Medicine, Aarhus University Hospital, Denmark
  3. 3
    Department of Cardiology, Odense University Hospital, Denmark
  1. Dr Michael Maeng, Department of Cardiology B, Aarhus University Hospital, Skejby, Brendstrupgaardsvej, DK-8200 Aarhus N, Denmark; michael.maeng{at}ki.au.dk

Abstract

Objective: We sought to assess vascular remodelling and neointima formation after implantation of bioabsorbable magnesium alloy stents (AMS).

Design: Randomised experimental study.

Interventions: AMS (n = 11), sirolimus-eluting stents (Cypher; n = 11) and bare-metal stents (BMS; n = 9) were randomly implanted in 31 porcine coronary arteries (n = 11 pigs).

Main outcome measures: Neointima formation was measured by histomorphometry at 90 days. Vascular remodelling defined as change in external elastic membrane area from index intervention to follow-up was assessed by serial intravascular ultrasound (IVUS).

Results: By histomorphometry, lumen (median (quartiles); AMS: 1.75 mm2 (1.07–3.26), Cypher 2.52 mm2 (2.22–5.01), BMS 4.55 mm2 (3.2–7.44); p = 0.013) and external elastic membrane area (AMS: 5.56 mm2 (4.09–6.95), Cypher 7.95 mm2 (6.45–10.92), BMS 9.08 mm2 (7.85–11.63); p = 0.014) were smallest after AMS implantation. By IVUS, external elastic membrane area at follow-up was smallest (AMS: 7.5 (2.8) mm2, Cypher 9.1 (2.7) mm2, BMS 9.9 (3.1) mm2; p = 0.33) and change in external elastic membrane area from index intervention to follow-up (remodelling; AMS: −1.0 (3.1) mm2, Cypher 1.0 (0.8) mm2, BMS 0.9 (1.2) mm2; p = 0.30) was greatest in the AMS group. In a dichotomised IVUS assessment of vascular remodelling, six AMS stents were remodelled (negative remodelling: n = 5; positive remodelling: n = 1) at 90-day follow-up (AMS versus Cypher + BMS: p = 0.001). Neointima formation was smallest in the AMS group (p<0.05 for both histomorphometry and IVUS).

Conclusion: Coronary implantation of absorbable magnesium stents, compared to two non-absorbable stents, was associated with the smallest lumen area at three-month follow-up because of negative vascular remodelling.

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Footnotes

  • Competing interests: None.

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