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The TNT study, women and cancer
  1. N K Wenger1,
  2. V Bittner2,
  3. D M Herrington3,
  4. S J Lewis4,
  5. F K Welty5
  1. 1
    Emory University School of Medicine, Atlanta, Georgia, USA
  2. 2
    University of Alabama at Birmingham, Birmingham, Alabama, USA
  3. 3
    Wake Forrest University School of Medicine, Winston-Salem, North Carolina, USA
  4. 4
    Northwest Cardiovascular Institute, Portland, Oregon, USA
  5. 5
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
  1. Professor N K Wenger, Division of Cardiology, Emory University School of Medicine, 49 Jesse Hill Jr Drive, Atlanta 30303, USA; nwenger{at}emory.edu

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The authors’ reply: We thank Drs Goldstein, Mascitelli and Pezzetta for raising the concern of a statin/oestrogen interaction and, possibly, a synergism between statins and oestrogen in raising the level of peripheral regulatory T-cell (Treg) concentration, given the evidence that oestrogen significantly increases Treg concentration.

An analysis of cancer deaths was undertaken in the women who took menopausal hormone therapy during …

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