The TNT study, women and cancer
- N K Wenger1,
- V Bittner2,
- D M Herrington3,
- S J Lewis4,
- F K Welty5
- 1Emory University School of Medicine, Atlanta, Georgia, USA
- 2University of Alabama at Birmingham, Birmingham, Alabama, USA
- 3Wake Forrest University School of Medicine, Winston-Salem, North Carolina, USA
- 4Northwest Cardiovascular Institute, Portland, Oregon, USA
- 5Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
- Professor N K Wenger, Division of Cardiology, Emory University School of Medicine, 49 Jesse Hill Jr Drive, Atlanta 30303, USA; nwenger{at}emory.edu
The authors’ reply: We thank Drs Goldstein, Mascitelli and Pezzetta for raising the concern of a statin/oestrogen interaction and, possibly, a synergism between statins and oestrogen in raising the level of peripheral regulatory T-cell (Treg) concentration, given the evidence that oestrogen significantly increases Treg concentration.
An analysis of cancer deaths was undertaken in the women who took menopausal hormone therapy during …
