Cardiovascular malformations are the most common type of birth defect. Currently, only a fraction of cases have associated causative factors and little is known about the aetiology of the rest. Despite this, our understanding of normal and abnormal heart development continues to grow, a number of recent discoveries even challenging long-held concepts. In this review, we highlight some of this new knowledge, emphasising aspects that may be of interest to the clinician.
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Additional references (w1–w59) are published online only at http://heart.bmj.com/content/vol95/issue6
Funding: BDK holds a chair from the British Heart Foundation.
Competing interests: None.
Patient consent: Obtained.