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Heart 96:36-41 doi:10.1136/hrt.2009.177113
  • Original article

Continuous, non-invasive measurement of the haemodynamic response to submaximal exercise in patients with diabetes mellitus: evidence of impaired cardiac reserve and peripheral vascular response

Table 1

Demographic profile of subjects

Normal (n = 32) HbA1C <8 (n = 31) HbA1C ⩾8 (n = 38)
Age (years) 48.8 (5.3) 50.6 (7.3) 50.3 (4.6)
BMI (kg/m2)‡ 23.81* (3.4) 26.42 (2.8) 26.57 (3.8)
Systolic blood pressure (mm Hg) 116 (10) 120 (12) 117 (11)
Diastolic blood pressure (mm Hg) 80 (9) 80 (7) 78 (9)
Cardiac output (l/ml) 4.96 (0.95) 5.10 (0.91) 5.19 (0.76)
Heart rate 77 (11) 80 (14) 80 (10)
NT-proBNP (pg/ml)† 31 (14.5–51.5) 35.1 (11.5–62.7) 27.6 (14.6–55.7)
VCAM (ng/ml)† 326.8 (186–647) 343.8 (171–617) 416.9 (253–611)
Diabetes duration (years)† 4 (3–10) 5 (3–10)
Microalbuminuria (mg/l) 18.99 (44.93) 17.85 (36.35) 41.05 (88.11)
eGFR (ml/min/1.73 m2) 85 (12) 80 (16) 90 (17)
Concomitant medication
    Secretagogues 70 73
    Sensitisers 73 76
    β-blockers‡ 33 5**
    Antihypertensives 50 34
    Diuretics 7 3
    Statins 8.3 0
  • Values are means (SD) or †median (interquartile range).

  • *p<0.01 normal vs <8, normal vs ⩾8; **p<0.05 <8 vs ⩾8.

  • ‡Does not alter and contribute to diabetic vs non-diabetic comparison for various ICG and O2C variables.

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