Alcohol intake and the risk of coronary heart disease in the Spanish EPIC cohort study
- L Arriola1,2,
- P Martinez-Camblor1,2,
- N Larrañaga1,2,
- M Basterretxea1,2,
- P Amiano1,2,
- C Moreno-Iribas1,4,8,
- R Carracedo1,2,
- A Agudo3,
- E Ardanaz1,4,
- A Barricarte1,4,
- G Buckland3,
- Lluis Cirera1,5,
- M D Chirlaque1,5,
- C Martinez1,6,
- E Molina1,6,
- C Navarro1,5,
- J R Quirós7,
- L Rodriguez7,
- M J Sanchez1,6,
- M J Tormo1,5,
- C A González3,
- M Dorronsoro1,2
- 1CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
- 2Public Health Department of Gipuzkoa, Basque Government, San Sebastian, Spain
- 3Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain
- 4Public Health Institute of Navarra, Pamplona, Spain
- 5Department of Epidemiology, Murcia Health Council, Murcia, Spain
- 6Andalusian School of Public Health, Granada, Spain
- 7Public Health and Health Planning Directorate, Asturias, Spain
- 8Doctoral degree programme at UAB, Department of Paediatrics, Obstetrics and Gynaecology and Preventive Medicine, Barcelona, Spain
- Correspondence to Mrs L Arriola, Public Health Department of Gipuzkoa, Basque Government, Av Navarra 4, San Sebastian 20003, Spain;
- Accepted 25 August 2009
- Published Online First 19 November 2009
Background: The association between alcohol consumption and coronary heart disease (CHD) has been widely studied. Most of these studies have concluded that moderate alcohol intake reduces the risk of CHD. There are numerous discussions regarding whether this association is causal or biased. The objective of this paper is to analyse the association between alcohol intake and CHD risk in the Spanish cohort of the European Prospective Investigation into Cancer (EPIC).
Methods: Participants from the EPIC Spanish cohort were included (15 630 men and 25 808 women). The median follow-up period was 10 years. Ethanol intake was calculated using a validated dietary history questionnaire. Participants with a definite CHD event were considered cases. A Cox regression model adjusted for relevant co-variables and stratified by age was produced. Separate models were carried out for men and women.
Results: The crude CHD incidence rate was 300.6/100 000 person-years for men and 47.9/100 000 person-years for women. Moderate, high and very high consumption was associated with a reduced risk of CHD in men: hazard ratio 0.90 (95% CI 0.56 to 1.44) for former drinkers, 0.65 (95% CI 0.41 to 1.04) for low, 0.49 (95% CI 0.32 to 0.76) for moderate, 0.46 (95% CI 0.30 to 0.71) for high and 0.50 (95% CI 0.29 to 0.85) for very high consumers. A negative association was found in women, with p values above 0.05 in all categories.
Conclusions: Alcohol intake in men aged 29–69 years was associated with a more than 30% lower CHD incidence. This study is based on a large prospective cohort study and is free of the abstainer error.
Funding This work was supported by grants from the Spanish Ministry of Health (FIS PI04/0104, PI04/1644, PI04/1822, PI04/2342, PI04/2188 and PI06/0365) and CIBERESP. The EPIC study received financial support from the European Commission (agreement SO 97 200302 05F02), the participating Regional Governments, the Red Temática de Investigación Cooperativa de Centros de Cáncer (RTICCC, C03/10) and the International Agency for Research on Cancer (agreement AEP/93/02).
Competing interests None.
Ethics approval The study was approved by an ethical review board
Patient consent Obtained.
Provenance and Peer review Not commissioned; externally peer reviewed.