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Aspirin and coronary artery disease
  1. Erik Lerkevang Grove1,
  2. Morten Würtz1,
  3. Gunnar Hilmar Gislason2,
  4. Steen Dalby Kristensen1,
  5. Anne-Mette Hvas3
  1. 1Department of Cardiology, Aarhus University Hospital, Skejby, Denmark
  2. 2Copenhagen University Hospital Gentofte, Hellerup, Denmark
  3. 3Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Denmark
  1. Correspondence to Dr Erik Lerkevang Grove, Department of Cardiology, Aarhus University Hospital, Skejby, Brendstrupgaardsvej 100, Aarhus DK-8200, Denmark; erikgrove{at}dadlnet.dk

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The Authors' reply: We appreciate the letter by Tormen et al1 in response to our paper.2 Atherosclerosis is a multifactorial, slowly progressing vascular disease involving the retention of cholesterol-containing lipoproteins and the generation of proinflammatory molecules that recruit macrophages and ultimately results in thickening of the vascular wall. However, thrombosis is mainly caused by platelet-dependent thrombus formation on pre-existing atherosclerotic plaques.3 Acknowledging that aspirin has anti-inflammatory activity, …

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    Eduardo M da Rosa William C Tormen Edna F Lopes