Article Text

PDF
Effect of postconditioning on infarct size in patients with ST elevation myocardial infarction
  1. Peder Sörensson1,
  2. Nawzad Saleh1,
  3. Frederic Bouvier2,
  4. Felix Böhm1,
  5. Magnus Settergren1,
  6. Kenneth Caidahl2,
  7. Per Tornvall1,
  8. Håkan Arheden3,
  9. Lars Rydén1,
  10. John Pernow1
  1. 1Department of Cardiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
  2. 2Department of Clinical Physiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
  3. 3Department of Clinical Physiology, Lund University Hospital, Lund, Sweden
  1. Correspondence to Peder Sörensson, Karolinska University Hospital, 171 76 Stockholm, Sweden; peder.sorensson{at}karolinska.se

Abstract

Background Small studies suggest that postconditioning reperfusion interrupted by brief repetitive cycles of reocclusions, may protect the myocardium in the clinical setting.

Objective To test the hypothesis that postconditioning limits infarct size in relation to the area at risk in patients with ST elevation myocardial infarction (STEMI).

Methods 76 patients (aged 37–87 years) eligible for primary percutaneous coronary intervention due to STEMI were randomised to standard percutaneous coronary intervention (n=38) or postconditioning, consisting of four cycles of 60 s reperfusion and 60 s of reocclusion before permanent reperfusion (n=38).

Results The area at risk was determined from angiographic abnormally contracting segments. Infarct size was quantified from delayed enhancement MRI on days 6–9. Infarct size, expressed in relation to the area at risk, did not differ between the control group (44%; 30, 56) (median and quartiles) and the post-conditioned group (47%; 23, 63). The slope of the regression lines relating infarct size to the area at risk differed between the two groups. Infarct size was significantly (p=0.001) reduced by postconditioning in patients with large areas at risk. The area under the curve and peak troponin T release and CKMB during 48 h did not differ between patients in the control and postconditioning groups.

Conclusions This prospective, randomised trial suggests that postconditioning does not reduce infarct size in patients with STEMI in the overall study group. The data indicate that postconditioning may be of value in patients with large areas at risk.

Clinical trial registration information Karolinska Clinical Trial Registration (http://www.kctr.se). Unique identifier: CT20080014.

  • Myocardial infarction
  • postconditioning
  • reperfusion injury
  • MRI
  • coronary intervention
  • coronary artery disease (CAD)
  • STEMI

Statistics from Altmetric.com

Footnotes

  • Funding Swedish Heart-Lung Foundation, Swedish Research Council of Medicine (10857, 14231), Stockholm County Council.

  • Competing interests None.

  • Ethics approval The study was approved by the local ethics committee at the Karolinska Institutet, Stockholm.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.