Article Text
BSCR Autumn Meeting Abstracts, 2009
Myocardial energetics and redox in health and disease
011 A new molecular mechanism for familial dilated cardiomyopathy based on studies with intact mutant transgenic mouse and human explanted heart muscle
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We created a transgenic mouse that expressed the dilated cardiomyopathy (DCM) mutation ACTC E361G at 50% of total cardiac actin. We isolated F-actin from transgenic and non-transgenic (NTG) mice and reconstituted thin filaments using native human cardiac troponin and tropomyosin (from donor heart). In in-vitro motility assays we could observe no differences between E361G and …