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BSCR Autumn Meeting Abstracts, 2009
Myocardial energetics and redox in health and disease
013 Regulation of gene transcription by hydrogen peroxide in cardiomyocytes
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  1. K Lay
  1. National Heart and Lung Institute, Cardiovascular Science, Imperial College London, London SW7 2AZ, UK

https://doi.org/10.1136/hrt.2009.191064a

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    Introduction

    Reactive oxygen species (ROS) levels rise during ischaemia and reperfusion and may contribute to myocardial injury, remodelling and progression to heart failure. ROS (hydrogen peroxide; H2O2) activates both apoptotic and pro-survival signalling pathways, although at higher concentrations cardiomyocyte death invariably results. Here, …

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