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  • 018 Guanidinoacetate N-methyltransferase knockout mice exhibit normal left ventricular remodelling, haemodynamics and survival after myocardial infarction despite lack of phosphocreatine

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BSCR Autumn Meeting Abstracts, 2009
Myocardial energetics and redox in health and disease
018 Guanidinoacetate N-methyltransferase knockout mice exhibit normal left ventricular remodelling, haemodynamics and survival after myocardial infarction despite lack of phosphocreatine
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https://doi.org/10.1136/hrt.2009.191064f

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    Guanidinoacetate N-methyltransferase (GAMT) catalyses the final step of creatine biosynthesis such that GAMT−/− mice have undetectable levels of phosphocreatine and creatine and accumulation of the precursor (phospho-)guanidinoacetate (PGA). Like phosphocreatine, PGA acts as an energy reservoir, but energy transfer via creatine kinase is 100 times slower. We hypothesised that reduced energy transfer …

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