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Adiponectin acts as a positive indicator of left ventricular diastolic dysfunction in patients with hypertrophic cardiomyopathy
  1. Kazumasa Unno1,
  2. Rei Shibata1,
  3. Hideo Izawa1,
  4. Akihiro Hirashiki1,
  5. Yosuke Murase1,
  6. Takashi Yamada1,
  7. Masakazu Kobayashi1,
  8. Akiko Noda2,
  9. Kohzo Nagata2,
  10. Noriyuki Ouchi3,
  11. Toyoaki Murohara1
  1. 1Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  2. 2Department of Medical Technology, Nagoya University School of Health Science, Nagoya, Japan
  3. 3Molecular Cardiology, Boston University School of Medicine, Boston, Massachusetts, USA
  1. Correspondence to Rei Shibata, Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya 466-8550, Japan; rshibata{at}med.nagoya-u.ac.jp

Abstract

Background Adiponectin is an adipose-derived plasma protein that exhibits beneficial actions on the heart. Recently, it was shown that adiponectin levels were elevated in patients with systolic heart failure.

Objective To investigate the association between adiponectin levels and left ventricular (LV) diastolic function in patients with hypertrophic cardiomyopathy (HCM), characterised by diastolic dysfunction.

Methods Twenty-six patients with HCM showing LV ejection fraction of >60% were enrolled. LV pressure half-time (T1/2) was measured as an index of myocardial relaxation. Patients were divided into two groups on the basis of baseline T1/2 (group A: T1/2< 35 ms, group B: T1/2≥ 35 ms). Blood samples were simultaneously collected from the coronary sinus (CS) and aortic root (Ao) as well as the peripheral vein (PV) for measurement of plasma adiponectin levels.

Results Plasma adiponectin levels were significantly higher in group B than in group A. Adiponectin levels in the PV were positively correlated with the baseline T1/2 in patients with HCM. The transcardiac gradient of adiponectin as calculated by the Ao−CS difference was significantly higher in group A than in group B. The transcardiac gradient of adiponectin also inversely correlated with the baseline T1/2 and adiponectin levels in PV in patients with HCM. The expression of AdipoR1 but not AdipoR2 in the heart decreased in group B. The baseline T1/2 was negatively associated with AdipoR1 expression in patients with HCM.

Conclusions These data document that adiponectin is an indicator of LV diastolic dysfunction in patients with HCM.

  • Adiponectin
  • hypertrophic cardiomyopathy
  • diastolic dysfunction
  • left ventricular hypertrophy
  • cytokines
  • HCM
  • hypertrophic cardiomyopathy
  • APN-KO
  • adiponectin deficient
  • LV
  • left ventricular
  • T1/2
  • left ventricular pressure half-time
  • LVEDP
  • left ventricular end-diastolic pressure
  • LVOT-PG
  • left ventricular outflow tract pressure gradient
  • E/Ea
  • early diastolic transmitral flow velocity/early diastolic annular velocity
  • PV
  • peripheral vein
  • CS
  • coronary sinus
  • Ao
  • aortic root

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Footnotes

  • Linked article 178590

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the ethics committee of the Nagoya University School of Medicine, Japan.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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