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Ethnicity-related differences in left ventricular function, structure and geometry: a population study of UK Indian Asian and European white subjects
  1. Navtej S Chahal1,
  2. Tiong K Lim1,
  3. Piyush Jain2,
  4. John C Chambers3,
  5. Jaspal S Kooner2,
  6. Roxy Senior1,2
  1. 1Department of Cardiovascular Medicine, Northwick Park Hospital, Harrow, UK
  2. 2National Heart and Lung Institute, Imperial College London, UK
  3. 3Department of Epidemiology and Public Health, Imperial College London, UK
  1. Correspondence to Professor Roxy Senior, Department of Cardiovascular Medicine, Northwick Park Hospital, Watford Road, Harrow HA1 3UJ, UK; Honorary Professor Middlesex University, London, UK; roxysenior{at}cardiac-research.org

Abstract

Objectives The authors studied healthy UK Indian Asian and European white subjects to assess whether functional, structural and geometrical properties of the left heart are intrinsically related to ethnicity.

Background Quantitative assessment of cardiac function and structure is necessary to diagnose heart failure syndromes and is validated to refine risk prediction. A better understanding of the demographic factors that influence these variables is required.

Methods 458 healthy subjects were recruited from the London Life Sciences Prospective Population (LOLIPOP) study. They underwent 2-D and tissue Doppler echocardiography for quantification of left ventricular (LV) function, LV volumes, left atrial volume index (LAVI), left ventricular mass index (LVMI) and relative wall thickness (RWT).

Results Indian Asians had attenuated mitral annular systolic velocity (8.9 cm/s vs 9.5 cm/s, p<0.001), lower mitral annular early diastolic velocity (10.3 cm/s vs 11.0 cm/s, p<0.001) and higher E/Ea ratio (7.9 vs 7.0, p<0.001) compared to European white subjects. Although Indian Asians had significantly smaller left heart volumes and LVMI, they had a significantly higher RWT (0.37 vs 0.35, p<0.001). After adjustment for covariates, these ethnicity-related differences remained highly significant (p<0.001).

Conclusion Compared to European white people, Indian Asians had attenuated longitudinal LV function, higher LV filling pressure and demonstrated a greater degree of concentric remodelling independent of other demographic and clinical parameters.

  • Left ventricular geometry
  • ethnicity
  • epidemiology

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Footnotes

  • Funding Cardiac Research Fund, Northwick Park Institute for Medical Research.

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the Northwick Park and Ealing Hospitals Research Ethics Committees.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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