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Subclinical anthracycline- and trastuzumab-induced cardiotoxicity in the long-term follow-up of asymptomatic breast cancer survivors: a speckle tracking echocardiographic study
  1. Emily Ho1,
  2. Angela Brown1,
  3. Patrick Barrett1,
  4. Roisin B Morgan1,
  5. Gerard King1,
  6. M John Kennedy2,
  7. Ross T Murphy1
  1. 1Department of Cardiology, St James's Hospital, Dublin, Ireland
  2. 2Department of Oncology, St James's Hospital, Dublin, Ireland
  1. Correspondence to Dr Emily Ho, Department of Cardiology, St. James's Hospital, Dublin 8, Ireland; emilyho28{at}gmail.com

Abstract

Objective To examine the long-term effects of standard chemotherapy on myocardial function in asymptomatic breast cancer survivors using two-dimensional speckle tracking echocardiography.

Methods Seventy women (chemotherapy group) aged 54±8 years who had received anthracycline treatment with (n=19) or without (n=51) adjuvant trastuzumab up to 6 years previously, and 50 female controls were studied. Left ventricular systolic (ejection fraction (EF%), peak systolic myocardial excursion, (Sm)) and diastolic (peak mitral E and A velocities, six-point average of mitral annular E′ velocities) function, 2D global and regional longitudinal and radial strain were determined using standard 2D Doppler and tissue Doppler echocardiographic methods and speckle tracking software.

Results Despite normal EF% (62±4% vs 60±3%, p=0.051) the chemotherapy group had reduced E/A ratios (0.9±0.3 vs 1.1±0.3, p=0.003), global E′ (10.2±2 vs 11.2±2.3, p=0.036), global Sm (9.0±1.3 vs 9.6±1.3, p=0.029) and global longitudinal 2D strain (−18.1±2.2 vs −19.6±1.8, p=0.0001) in comparison with controls. In 18 (26%) of the chemotherapy group, global longitudinal strain was below the lower limit of the control group. Cigarette smoking was a negative predictor of longitudinal strain, but only in the chemotherapy group. Radial strain did not differ significantly between the two groups. There were no significant differences in EF%, global Sm and longitudinal strain between trastuzumab-treated individuals and controls.

Conclusions Subclinical systolic and diastolic myocardial abnormalities were present in asymptomatic breast cancer survivors up to 6 years after standard chemotherapy. Cigarette smoking had a negative effect on longitudinal strain in these individuals. Adjuvant trastuzumab treatment did not appear to have an additive adverse impact on myocardial function in the medium–long term.

  • Anthracycline
  • trastuzumab
  • speckle tracking echocardiography
  • diastolic dysfunction
  • chemotherapy

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Footnotes

  • Funding This work was supported by the Royal City of Dublin Hospital Trust (grant number 119) in a grant awarded to Dr Emily Ho.

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the St James's Hospital Research Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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