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Clinical and research medicine: Cardiovascular clinical pharmaceutical research
e0325 Influence of probucol on endothelial dependent vasodilation reaction in patients with acute coronary syndrome
  1. Hong-Mei Dong,
  2. Lan Huang,
  3. Yao-Ming Song,
  4. Ai-Min Li,
  5. Jun Jin,
  6. Gang Zhao,
  7. Chun-Mei Lin,
  8. Chun-rong Tao
  1. Xinqiao Hospital, Third Military Medical University

Abstract

Objective The study tested the antioxidant probucol for endothelial dependent vasodilation reaction in the patients of ACS after received therapy.

Methods 51 ACS patients were divided randomly into a probucol treatment group (p) and a routine treatment group (C). Oxidised low-density lipoprotein (ox-LDL) was measured in peripheral blood by Sandwich ELISE method. The brachial arterial hyperaemia-induced flow mediated dilation (FMD) and sublingual nitroglycerin (NTG) mediated vasodilation were measured by high resolution ultrasound. These variables were analysed after received probucol 3 months.

Results The level of FMD with probucol treatment group was significantly increased after 3 months compared to pretreamented (p<0.05), while the level of ox-LDL in peripheral blood in ACS patients was markedly diseased (p<0.01). The FMD with probucol treatment group was significantly increased compared to ACS routine treatment group (p<0.05), while the level of ox-LDL was markedly desaesed (p<0.01). The linear correlation analysis showed that plasma ox-LDL was a negative correlation with FMD in after treatmented patients by probucol with ACS (r=−0.517, p<0.001).

Conclusions It was important that vascular endothelial function and endothelial dependent vasodilation reaction may be improved in the ACS patients of after the antioxidant probucol therapy.

  • Acute coronary syndrome
  • probucol
  • oxidative low density lipoprotein

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