Objective The study tested the antioxidant probucol for endothelial dependent vasodilation reaction in the patients of ACS after received therapy.
Methods 51 ACS patients were divided randomly into a probucol treatment group (p) and a routine treatment group (C). Oxidised low-density lipoprotein (ox-LDL) was measured in peripheral blood by Sandwich ELISE method. The brachial arterial hyperaemia-induced flow mediated dilation (FMD) and sublingual nitroglycerin (NTG) mediated vasodilation were measured by high resolution ultrasound. These variables were analysed after received probucol 3 months.
Results The level of FMD with probucol treatment group was significantly increased after 3 months compared to pretreamented (p<0.05), while the level of ox-LDL in peripheral blood in ACS patients was markedly diseased (p<0.01). The FMD with probucol treatment group was significantly increased compared to ACS routine treatment group (p<0.05), while the level of ox-LDL was markedly desaesed (p<0.01). The linear correlation analysis showed that plasma ox-LDL was a negative correlation with FMD in after treatmented patients by probucol with ACS (r=−0.517, p<0.001).
Conclusions It was important that vascular endothelial function and endothelial dependent vasodilation reaction may be improved in the ACS patients of after the antioxidant probucol therapy.
- Acute coronary syndrome
- oxidative low density lipoprotein