Background Prior studies indicated that lipoprotein (a) is an independent risk factor for coronary atherosclerosis, but the relationship of serum lipoprotein (a) and coronary artery calcification is still poorly understood in Chinese population.
Objective The present study is to investigate the human lipid profile of a single center (lipoprotein (a), other blood lipid levels) with the relationship of coronary artery calcification.
Method 388 patients suspected with coronary artery disease under coronary CT examinations from March 2007 to June 2009 in our hospital were recruited. The patients were divided into three groups according to their risk factors. The patients without hypertension and diabetes were included into Group A (n=95). The patients with high blood pressure or diabetes were included into group B (n=221) and the patients with both of high blood pressure and diabetes were included into group C (n=72). Coronary artery calcification score, lipid profiles (lipoprotein (a), LDL, HDL, TG, TC) and coronary angiography were determined in each group.
Results Among the 3 groups, there is no significant difference between sex, drinking history, smoking history; there is significant difference between age and the incidence of coronary heart disease among the 3 groups (age F=5.737, p=0.005; coronary heart disease F=6.283, p=0.002. Coronary artery calcification score is significantly higher in group C than that of groups A (groups C 256.9±430.199 VS group A 103.74±299.85, p=0.011). Coronary artery calcification score was positively correlated with lipoprotein (a) (p=0.005), age (p=0.021) in group A. Coronary artery calcification score was positively correlated with low-density lipoprotein (p=0.018), age (p=0.000) in group B. There is no significantly correlation between coronary artery calcification score and lipid profiles in group C. Summary analysis coronary artery calcification score was positively correlated with LP (a) (p=0.013), low-density lipoprotein (p=0.021), age (p=0.000).
Conclusion In the low-risk coronary heart disease group, lipoprotein (a) is positively correlated with coronary calcification score, which suggests lipoprotein (a) is an independent risk factor for coronary artery calcification for these apparently low risk patients. The present study may contribute to the early diagnosis and intervention of coronary artery disease for those patients.