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Clinical and research medicine: Cardiovascular clinical pharmaceutical research
e0346 Screening of sleep apnoea-hypopnoea syndrome from ECG derived respiration of ambulatory ECG
  1. Guangming Tong Guangming Tong1,
  2. Haicheng Zhang Haicheng Zhang2,
  3. Jihong Guo Jihong Guo2,
  4. Fang Han Fang Han3
  1. 1Department of Cardiology The Second Hospital Affiliated To Soochow University
  2. 2Department of Cardiology, Peking University Peoples Hospital
  3. 3Sleep Center of Peking University Peoples Hospital

Abstract

Objective To evaluate the feasibility of screening sleep apnoea- hypopnoea syndrome (SAHS) from ECG–derived respiration (EDR) of ambulatory ECG (AECG) monitoring.

Methods The overnight sleep investigation was administered to 80 subjects by polysomnogram (PSG) and 24 h AECG monitoring simultaneously during February through November, 2004. The ECG analysers did not know the PSG results at all. They were both asked to give the apnoea hypopnoea index (AHI) by EDR and PSG respectively. The PSG result was considered as the gold standard so as to evaluate the feasibility of screening SAHS from EDR of AECG monitoring.

Results The average age, male gender, body mass index, history of hypertension were higher in the SAHS (+) patients than those of the SAHS (-) patients. Automatic analysis was performed with software in a sensibility of 75%, 87.5% and 100% respectively. When software sensibility adjusted to 75%, the sensitivity of screening SAHS with EDR was 26.7%, with the specificity of 80%, the positive predictive value of 80%, the negative predictive value of 26.7%, the diagnose accordance rate of 40%. When software sensibility was adjusted to 87.5%, the sensitivity of screening SAHS with EDR was 55%, with the specificity of 45%, the positive predictive value of 75%, the negative predictive value of 25%, and the diagnose accordance rate of 52.5%. When software sensibility was adjusted to 100%, the sensitivity of screening SAHS with EDR was 88.3%, with the specificity of 35%, the positive predictive value of 84.1%, the negative predictive value of 50%, and the diagnose accordance rate of 75%.

Conclusion EDR technique of AECG was useful to screen the suspicious SAHS patients, sensitivity and the diagnosis coincidence rate was higher when the sensibility of automatic analysis software was adjusted to 100%.

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