Objective To study the predictive value of score of intima-media thickness (IMT), Crouse in carotid artery plaque, and serum levels of high sensitivity C-reactive protein (hs-CRP) in the degree of coronary stenosis of patients with coronary artery disease.
Methods A total of 110 patients suspected coronary heart disease with chest pain were admitted to this study. They were divided into two groups: group of coronary heart disease and group of normal control according to the results of CAG. All patients underwent carotid ultrasonography within a week, and carried out the testing of serum concentrations of hs-CRP in second hospitalised day, to assess the determining and forecasting value of score of IMT and Crouse in carotid artery plaque, combining with serum levels of hs-CRP in the degree of coronary stenosis of patients with coronary artery disease.
Results Serum concentrations of hs-CRP, score of IMT, Crouse of group CHD were significantly higher than those of group non-CHD (p<0.01), and each mentioned indicators in group CHD was positively correlated with the degree of coronary stenosis(r>0.6, p<0.05). Taking Crouse points≥10.7 as a standard, its sensitivity was 78.5%, positive predictive value was 89.9%, specificity was 79.0%, negative predictive value was 58.0%.
Conclusion There was a high consistency between serum concentrations of hs-CRP, score of IMT, Crouse and the degree of coronary stenosis, so we can use serum concentrations of hs-CRP, score of IMT, Crouse as a prediction method to coronary heart disease in patients with carotid artery atherosclerosis.
- Coronary artery disease
- carotid artery plaque
- high sensitivity C-reactive protein