Objectives An increasing number of patients undergoing percutaneous coronary intervention (PCI) have experienced previous revascularization procedures. However risk factors associated with secondary percutaneous coronary revascularization and their effect sizes were lack of research. The purpose of this large scale cross-sectional survey was to investigate quantitative effect of cardiovascular risk factors.
Methods Patients with coronary heart disease hospitalised in the Department of Cardiology of Beijing Anzhen Hospital whose disease was identified by angiography were consecutively enrolled into the present study from January 2006 to July 2009. Demographic information, concomitant diseases, peri-operative laboratory examinations, angiographic features, and surgery information of consecutive patients who underwent PCI were collected.
Results A total of 13 922 patients were recorded in the database, of which 9.03% (1257/13, 922) had previous PCI. Univariate analysis revealed that patients with prior PCI had significant higher prevalence of hypertension, diabetes mellitus and hyperlipidaemia than those without prior PCI. In addition, the percentage of patients with prior CABG was higher in the former group (6.0% vs 1.9%, p<0.001). In multivariable logistic regression analyses adjusted for demographic, clinical, angiographic and procedural factors, elderly age (OR 1.01, 95% CI 1.00 to 1.01), male (OR 1.74, 95% CI 1.48 to 2.04), hypertension (OR 1.36, 95% CI 1.19 to 1.54), diabetes mellitus (OR 1.43, 95% CI 1.24 to 1.63), hyperlipidaemia (OR 1.30, 95% CI 1.06 to 1.57) and prior CABG (OR 3.37, 95% CI 2.52 to 4.51) were identified as independent risk factors of secondary PCI. Additionally, history of prior CABG was the most important predictor of secondary PCI.
Conclusions Risk factors associated with secondary PCI include elderly age, male, hypertension, diabetes mellitus, hyperlipidaemia and prior CABG, of which previous CABG was the most important.