Objective To study the clinical Clinical and coronary angiography characteristics between young (≤45) and old (>60) patients with coronary artery disease.

Methods Angiographic and clinical data from A: 176 patients (≤45) selected from 1795 patients with coronary artery disease from April 2006 to May 2010 were compared to B: 464 patients (>60) with coronary artery disease from April 2007 to May 2009 in our department.

Results (1) The male in A much more than B (93.1% vs 61.4%, p<0.01). (2) The patients with hypertension or type 2 diabetes mellitus in A were less than B (all p<0.01). (3) The patients with Smoking, taking drug named Anajia or a positive family history in coronary artery disease in A were much more than B (all p<0.01). The incidences of dyslipidemia in A were more than B (28.2% vs 19.0%, p<0.05). (4) The patients because of acute myocardial infarction come to hospital were more than B (72.0% vs 62.5%, p<0.01). (5) Auto driver, the self-employed and government functionary were the top three categories of the coronary heart disease, but farmer, worker and retired military cadre in B. (6) Morbidity: the patients (≤45) with coronary artery disease accounted for 9.7% in all patients with coronary artery disease in the same time (the cases 82 (≤40) accounted for 4.6%). (7) The patients done coronary angiography in A were more than B (64.0% vs 38.1%, p<0.01). Singer vessel coronary artery diseases were seen more frequently in A than B (50.9% vs 21.5%, p<0.01), and especially left anterior descending branch diseases occupied 87.7%; two-vessel diseases and collateral circulation were less in A than B (all p<0.05); three-vessel diseases, right coronary artery and circumflex diseases were less in A than B (all p<0.01); however lesions and left main artery, left anterior descending branch diseases have no statistics meaning in A and B. The meaningless lesion coronary arteries diseases were much more in A than B (89.0% vs 0.6%, p<0.01), The myocardial infarction patients′ account for 90% in the groups who had meaningless coronary arteries change showed by coronary angiography in A.

Conclusion The feature of coronary heart disease (≤45): (1) Most because of acute myocardial infarction come to hospital; (2) The male, short of labour, more tension, heavy work pressure, the incidences of dyslipidemia, smoking and the early onset group had stronger family history of coronary arteries diseases were high risk groups, The patients taking Anajia may also the high risk groups in our area. (3) Morbidity: accounted for 9.7% in all patients with coronary artery disease in the same time (the cases (≤40) accounted for 4.6%). (4) (4) The coronary angiography characteristics about half is the single vessel diseases, especially left anterior descending branch diseases; coronary angiography in some patients has no significant lesions, and mainly to myocardial infarction; there were differences about two and three-vessel diseases, right coronary artery and circumflex diseases, collateral circulation between young (≤45) and old (>60); there were not differences about the left main coronary arteries diseases, left anterior descending branch diseases and the degree of narrowed coronary arteries between young (≤45)and old (>60).