Article Text

PDF

Clinical and research medicine: Acute coronary syndrome
e0460 Effect of Shengmai Injection (SMI) on blood vascular endodermis function and cardiac function in coronary artery disease with type 2 diabetes patients
  1. Zhang Yachen,
  2. Chen Man-Tian,
  3. Wang Fei,
  4. Rong Yezhi,
  5. Lu Baojing
  1. Division of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University

Abstract

Objective To investigate the drug effects of Shengmai Injection (SMI) on blood vascular endodermis function and cardiac function in coronary artery disease (CAD) with type 2 diabetes mellitus (2-DM) patients.

Methods A total of 120 patients with type 2 diabetes mellitus and CAD diagnosed by coronary angiography (CAG) were randomised into two groups, the control group, treated with conventional therapy and the SMI group, treated with SMI. The patients ’ nitrite oxide (NO), Endothelin-1 (ET-1), AngII in venous blood were noted, and the blood vascular endodermis function, cardiac function were measured before treatment and after 3 weeks treatment, so as to observe and compare their changes in the two groups.

Results After 3 weeks of treatment, the serum content of NO was significantly higher, the serum content of ET-1 and AngII were significantly lower in the SMI group than that in the control group (p<0.01); The patients’ blood vascular endodermis function and cardiac function were improved in SMI group than that in the control group (p<0.01).

Conclusion The SMI could not only improve the blood vascular endodermis function but also improve the cardiac function in coronary artery disease with type 2 diabetes mellitus patients.

  • Shengmai Injection (SMI)
  • coronary artery disease (CAD))
  • type 2 diabetes
  • blood vascular endodermis function
  • cardiac function Key words Shengmai Injection (SMI)
  • coronary artery disease (CAD))
  • type 2 diabetes
  • blood vascular endodermis function
  • cardiac function

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.