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Clinical and research medicine: Acute coronary syndrome
e0462 Relationship between red cell distribution width and complication risk in patients with acute myocardial infarction
  1. Kaizu Xu1,
  2. Liming Lin2,
  3. Jinxiu Lin3,
  4. Jiansheng Zheng1,
  5. Dingnan Cai1
  1. 1Medical College of Putian University, Putian
  2. 2The Affiliated Hospital, putian University
  3. 3Department of Cardiology, The First Affiliated Hospital, Fujian Medical University

Abstract

Objective To investigate the relationship between red cell distribution width (RDW) level and risk of complication in acute myocardial infarction (AMI) patients; to compare the correlation of RDW with NT-proBNP, cTnI and hs-CRP.

Methods From January 2006 to December 2009, 200 consecutive AMI patients admitted in cardiology department of affiliated hospital of putian university were enrolled. Patients were classified into complication group (n=145) or complication-free group (n=55) according to the presence or absence of new-onset symptomatic heart failure, arrhythmia or cardiac shock. Patients were divided into quartiles based on RDW value (≤12.8%, 12.9%–13.8%, 13.9%–14.7%, ≥14.8%, n=50 in each quartile), and OR of incident complication was calculated by using logistic regression. Correlation of RDW with NT-proBNP, cTnI and hs-CRP was compared by spearman rank correlation analysis.

Results RDW levels in complication group was significantly higher than that in Complication-free group (14.5±0.97 % vs 12.9±0.85%, p<0.05). RDW levels of AMI patients were positively associated with complication risk, after adjustment for estimated glomerular filtration rate, serum ferrum, left ventricular end-diastolic dimension, left ventricular ejection fraction, and plasma NT-proBNP, cTnI and hs-CRP levels, the highest RDW quartile entailed 1.96 times greater risk for complication than the lowest quartile (95% CI 1.34–2.79, P cTnI > hs-CRP (rs=0.31, 0.29 and 0.21 respectively, all p<0.05).

Conclusion Higher RDW is closely associated with increased risk of AMI complication and elevated plasma NT-proBNP and cTnI level.

  • Red cell distribution width
  • acute myocardial infarction
  • complication
  • N-terminal pro-brain natriuretic peptide
  • Troponin I

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