Objective The aim of the present study was to assess the influence of anaemia on development of contrast-induced acute kidney injury (AKI) after percutaneous coronary intervention.
Methods The subject group consisted of 1026 patients who had undergone coronary intervention procedure between January 1, 2008 and October 31, 2009. A nonionic, low osmolality contrast agent was used in our laboratory at this time. Serum creatinine values were measured before and within 48 h of administration of contrast agents. Contrast-induced nephropathy was defined as an increase of 3 0.5 mg/dl or 3 25% in serum creatinine concentration over baseline within 48 h of angiography, Anaemia as haemoglobin (Hgb) 120 g/l in women and 130 g/l in men.
Results Among the 1026 patients studied, 32 (3.1%) experienced AKI after procedure. AKI occurred in 6.3% of the anaemic patients and 2.2% of the non-anaemic patients (p 0.05). Multivariate logistic regression analysis found that baseline creatinine clearance and baseline haemoglobin were independent predictors of AKI. When presence of anaemia was introduced into the multivariate model instead of baseline haemoglobin, it was also showed a significant association with AKI.
Conclusion Anemia increases the incidence of AKI in patients with moderate renal dysfunction. Patients with both preexisting renal insufficiency and anaemia are at high risk of AKI. Baseline creatinine clearance and baseline haemoglobin (or anaemia) are independent predictors of AKI.