Objective To assess the effect of the Zeek aspiration thrombectomy catheter and tirofiban in the myocardial reperfusion and clinical prognosis in patients with acute ST-segment elevation myocardial infarction (AMI) who were undergone primary percutaneous coronary intervention (PCI).

Methods 84 patients of AMI with thrombotic burden lesion confirmed by coronary angiography were randomly divided into the aspiration catheter and tirofiban group (n=42) and standard percutaneous coronary intervention (PCI) group (n=42). Compared the TIMI flow grade, myocardial blush grade (MBG), ST segment resolution, left ventricular ejection fraction (LVEF) post PCI, haemorrahage and major adverse cardiac events (MACE) rate during hospitalisation between two groups.

Results Compared with control group, the study group improved TIMI flow grade, improved MBG and high LVEF, while the difference of MACE and haemorrahage rate during hospitalisation was nonsignificant.

Conclusion In AMI patients treated with primary PCI, Combination of thrombus aspiration and tirofiban was safe and effective, which could lower thrombosis burden, improve distal myocardium perfusion and cardiac function after procedure, did not increase the incidence of MACEs.