Objective This study sought to investigate the impact of ageing on left atrium thrombus in patients with non-valvular atrial fibrillation (AF).
Methods Four hundred and twenty-one consecutive patients with AF underwent transesophageal echocardiography prior to AF ablation were included in a prospectively established database. The elderly group was defined as age more than 65 years old.
Results In all the 421 patients, 108 (25.6%) were in the elderly group and 313 (74.4%) were in the young group, with the mean age 70.0±3.7, 52.1±8.5, respectively. There was no significant difference of left atrium thrombus between the elderly group and the young group (4.6% vs 6.7%, p=0.439). It was shown there is less value for age predicting left atrium thrombus, the area under the receptor-operating curve was 0.494. The mean age (56.7±9.9 vs 56.7±10.9, p=0.989) and the proportion of the elderly (19.2% vs 26.1%, p=0.439) did not differ significantly between the patients with left atrium thrombus and those without. After adjustment for ejection fraction, heart failure, hypertension, diabetes mellitus, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers medication in logistics multivariate analysis, left atrium diameter, non-paroxysmal AF, prior thromboembolic history were independent risk factors of left atrium thrombus. However, age was not an independent risk factor of left atrium thrombus.
Conclusions Ageing itself was not a risk factor of left atrium thrombus in patients with non-vavular AF.