Objective To investigate the clinical efficacy of the treatment of essential hypertension combined nifedipine sustained-release tablets with betaloc.
Methods 60 cases of essential hypertension discovered recently were divided into two groups in random, 30 patients in each group. The control group were given nifedipine sustained-release tablets 10 mg, twice a day at 08:00 and 20:00 oral; treated group were at the same of nifedipine sustained-release tablets with control group, but increased betaloc 25 mg before lunch. Measured blood pressure twice a week and total of 8 weeks.
Results In control group, significant therapeutic effect in 11 cases, there were clear therapeutic effect in 11 cases, no treatment effect in 8 cases, the total therapeutic efficacy was 73.3%; In treated group, significant therapeutic effect in 18 cases, there were clear therapeutic effect in 11 cases, no treatment effect in 1 cases, the total therapeutic efficacy was 96.7%; There was significant difference between two groups (X2=7.13, p<0.05). In control group, there was no significant change in heart rate (p>0.05); But in treatment group, heart rate decreased at average of 10 times min−1, There was obvious difference in Statistics (p<0.05).
Conclusions It is a good way to treat essential hypertension combined nifedipine sustained-release tablets with betaloc, and there is a mutual synergy, worthy to be popularised.
- nifedipine sustained-release tablets
- essential hypertension