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Basic science: Cardiovascular disease basic research
e0055 Relationship between Genetic polymorphism of cytochrome P4502C19 and coronary artery disease in Xinjiang Uigur population
  1. Yang Yining,
  2. Ma Yitong,
  3. Wang Xinlei,
  4. Liu Fen,
  5. Xiang Xie
  1. Department of Cardiology, The First Affiliated Hospital Xinjiang Medical University

Abstract

Objective To study the relationship between cytochrome P450 family 2C19 subfamily genetic polymorphism and coronary artery disease in Xinjiang Uigur Population.

Methods There are (del) 370 CAD patients and 190 control subjects, who (del) were tested for the genotypes for the (of) CYP2C19 SNPs rs4986893 with the methods (use) of PCR and analysed by restriction fragment length polymorphism. Blood press, (del) (,) plasma biochemical results and smoking were also included (del) (assessed). Statistic analyses were (del) (analysation was) performed with the SPSS 12.0 software package. The Hardy–Weinberg equilibrium was tested in all the groups.

Results Uigur, the genotypes distribution of the control group and the CHD group were in the Hardy–Weinberg equilibrium the (del), p>0.05(for case p=0.2, for control p=0.068). The frequency of AA, AG and GG were 0.3%, 0.5% and 94.3% in the CAD group, compared with the control group that were 0.6%, 5.6% and 93.8% respectively. For x2=0.107, the p value was 0.743. There was no significant difference in between the two groups. But the (amt?level???) blood glucose in the two groups had a difference (del). Smoking was also different in the CAD and the control groups (p=0.0002).

Conclusions The distribution frequency of the CYP2C19 SNPs rs4986893 genotypes in the Uigur population with or without CAS is not significantly different with the blood glucose and smoking both have correlation with CAD (del).

  • Genetic polymorphism
  • cytochromeP4502C19
  • coronary artery disease
  • Xinjiang Uigur population

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