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Basic science: Cardiovascular disease basic research
e0057 Correlation of ABCA1 Gene R219K in the Uighur National Minority in xinjiang with lipidmetabolism and the risk of MI
  1. Sun Minghui,
  2. Ma Yitong,
  3. Yang Yining
  1. Department of Cardiology, The First Affiliated Hospital, Xinjiang Medical University

Abstract

Objective To study the correlation of ATP binding cassette transporter A1 (ABCA1) and the gene polymorphism of R219K in the Uighur National Minority in Xinjiang patients with myocardiac infarction (MI), and to find the association of ATP binding cassette transporter A1 gene R219K common variant with the risk of the Uighur National Minority in Xinjiang patients with MI.

Methods The association of the gene polymorphism of R219K in 150 cases with the Uighur National patients with MI (test group) and 200 cases (control group) were detected by restriction fragment length polymorphism (RFLP) and PCR.

Results The 219K site genotype of ABCA1 gene in MI patients was obviously lower than that in control group (p<0.001), and high density lipop rotein (HDL) in allel K carriers was obviously higher than non-allel K carriers (p<0.05). Triglyeride (TG) was obviously less than in non-allel K carriers (p<0.05).

Conclusion Polymorphism of ABCA1 Gene R219K in the Uighur National is concerned with MI and HDL cholesterol and TG met- abolism.

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