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Clinical and research medicine: Hypertension
e0583 The intervention role of Valsartan on left ventricular hypertrophy and high-sensitivity C-reactive protein i n hypertension patients
  1. Cen Qiang,
  2. Yang Ming,
  3. Zhao Yan
  1. Fuxing Hospital Affiliated Capital Medical Univercity/ccu

Abstract

Objective To explore the relationship between high-sensitivity C-reactive protein (hs-CRP) and left ventricular hypertrophy (LVH) and to examine whether angiotensin receptors antagonist ARB could decrease CRP expression, block or invert the progression of LVH with essential hypertension (EH).

Methods 186 EH patients were divided into LVH group (n=92) and non-LVH group (n=94) by Devereux standard. All patients received Valsartan therapy for 24 w t o detect blood pressure, hs-CRP and left ventricularmass index (LVM I) 1.

Results The hs-CRP level of LVH group was higher than that of non-LVH group. Hs-CRP was positively correlated with LVM I. Hs- CRP decreased obviously in non- LVH and LVH group s after treat ment. LVM I decreased significantly than before treatment in LVH group (p<0.01).

Conclusions Plasma hs-CRP level is an independent risk factor for the development of LVH in EH. Valsartan treatment can decrease the incident LVH by reducing hs-CRP.

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