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Clinical and research medicine: Hypertension
e0586 Effect of glomerular filtration rate and microalbuminuria on the damage of target organ in essential hypertension
  1. Zhang Ying,
  2. Xu Xinjuan,
  3. Simayi Zhulepiya,
  4. Chen Yulan
  1. The First Teaching Hospital of Xinjiang Medical University

Abstract

Objective To observe the character of Ambulatory Blood Pressure Monitoring and the damage of target organs in hypertensive patients with abnormal GFR and (or) MAU. To observe the correlated factors of GFR and MAU.

Methods Our study population consisted of 202 cases of essential hypertensive patients (male 109, female 93, Han people 128, wei people 52, other race people 22, age 18–82 years, mean age is 44.39±11.32 years). Based on the value of GFR and MAU, the patients were divided into three groups and two groups departedly. To analyse the index of ambulatory blood pressure, blood fat, blood glucose and the degrees of the damage of target organ in these groups. To analyse the correlation factor of GFR and MAU with statistical method.

Results (1) The all systolic blood pressure, the diastolic blood pressure in night and the pulse pressure in GFR<60 ml/min/1.73 m2 group is higher than the other two groups. The incidence of Ventriculus sinister plump, carotid arteries, abnormal cerebral blood flow in GFR<60 ml/min/1.73 m2 group is higher than the other two groups. (2) The all index of ambulatory blood pressure except the morning systolic and diastolic blood pressure, blood fat and blood glucose in 24 h MAU≥30 mg/d group is higher than the other group. No difference on the damage of target organ in these two groups. (3) The regression result display that GFR is associated with age and serum creatinine. MA is associated with the systolic blood pressure, fasting blood glucose and GFR.

Conclusions There is show that the cardiovascular incidence rate in essential hypertension patients with renal dysfunction is higher than pure essential hypertension. GFR is decline with the raise of age and serum creatinine. MA is increased with the decline of GFR and the raise of systolic blood pressure, fasting blood glucose.

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