Objective To investigate association of left ventricular hypertrophy (LVH) with renal function in patients with essential hypertension.
Methods 318 patients with essential hypertension hospitalised in the department of Cardiology of First Hospital of China Medical University between 2008 and 2010 were investigated. Glomerular filtration rate (eGFR) was estimated by serum keratinise (Scr), age and sex, Left ventricular mass index was determined using echocardiography. Patients were divided into two groups, LVH group and non-LVH group.
Results Difference of age, sex, course, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), uric acid (UA), total cholesterol (TC), triglyceride (TG), fasting blood glucose (FBG) between two groups were of no statistical significance. Mean eGFR was 77.43±26.38 ml/min/1.73 m2 in LVH group and 83.74±23.70 ml/min/1.73 m2 in non-LVH group (p>0.05). However, the slope of the regression line of eGFR vs age was accentuated (p<0.05) in LVH group (slope values of −1.818±0.303 ml/min/1.73 m2 per year) when compared with non-LVH group (slope values of −0.902±0.304 ml/min/1.73 m2 per year).
Conclusion LVH accelerates decline of eGFR with age; LVMI appeared to be a potential marker of accelerating age-associated decline of eGFR.
- Essential hypertension
- left ventricular hypertrophy
- glomerular filtration rate