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Clinical and research medicine: Heart failure and left ventricular function
e0614 LV diastolic relaxation and filling assessment using the time interval between mitral inflow and mitral annular velocities
  1. Huang Feiqiong1,
  2. Zhang Ruisheng2,
  3. Le Thuthao1,
  4. Tan Rusan1
  1. 1National Heart Centre Singapore, Singapore
  2. 2Beijing Hospital, Beijing, China


Objective The aim of ours study was to evaluate the left ventricular (LV) function using the time intervals between peak mitral inflow and peak mitral annular velocities.

Methods This study included 39 patients with heart failure, left ventricular hypertrophy (LVH) and ischaemic heart disease (age from 29 to 56 years old, mean age: 36 years), and 23 age-matched healthy controls (age from 30 to 50 years). According to the filling pattern, patients were classified into 2 groups: (1) impaired relaxation group and (2) restrictive filling pattern group. The measurements were: the time intervals from the R-wave on the ECG to the peak E-wave on the transmitral flow (TMF) (R-pE), to the peak E’-wave on the LV lateral wall of tissue Doppler imaging (TDI) (R-pE’); The time intervals from the onset of P-wave on the ECG to the peak A-wave on the TMF (P-pA), to the peak A’-wave (P-pA′) on TDI. Early-diastolic temporal discordance (EDTD) and late-diastolic temporal discordance (LDTD) were calculated as the difference between the time intervals (R-E) and (R-E′), (P-pA) and (P-p A′).

Results EDTD and LDTD were significantly decreased in the impaired relaxation group and restrictive filling pattern group compared with control group respectively (20.6±28.3, 9.1±14.3 vs 34.5±22.3, p<0.001), (16.4±15.2, 3.5±22.6 vs 31.4±13.0, p<0.001).

Conclusions EDTD and LDTD, which mean the LV relaxation and left atrial contraction, may be a useful new method to evaluate the LV diastolic function in patients with heart diseases.

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