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Clinical and research medicine: Heart failure and left ventricular function
e0636 The relationship study between BNP levels and CK-MB, cTNI concentrations, the degree of coronary artery disease, heart function in patients with ST-segment elevation acute myocardial infarction
  1. Fu Xianghua,
  2. Wang Xuechao,
  3. Fan Weize,
  4. Wu Weili,
  5. Wang Yanbo,
  6. Gu Xinshun,
  7. Jiang Yunfa,
  8. Hao Guozhen
  1. The Second Hospital of Hebei Medical University

Abstract

Objective To analysis the relationship between BNP levels and CK-MB, cTNI concentrations, the degree of coronary artery disease and heart function in patients with acute ST-segment elevation myocardial infarction (STEMI).

Methods A total of 86 patients with AMI got intravenous thrombolysis within 6 h after myocardial infarction were divided into group A (BNP<100 pg/ml), group B (BNP100–500 pg/ml), C group (BNP>500pg/ml) according to the BNP peak level. The BNP level, CK-MB, and the cTNI peak concentrations within 24 h were examined. The heart function was examined by UCG within one week, cardioangiography was performed within 7–10 days after AMI, so that to evaluate the relationship between BNP levels and CK-MB, cTNI concentrations, the degree of coronary artery disease, heart function.

Result There were no statistical differences in baseline data among A, B, C groups, the higher the BNP level. The higher the CK-MB level (p<0.05), so is the cTNI peak level (p<0.05). There was a significantly correlation between BNP peak levels and CK-MB, cTNI peak concentrations, while the higher the BNP level, the lower the LVEF was (p<0.05), there was a significantly negatively correlation between BNP peak level and LVEF. Leaman coronary score show that scores in group C are higher than that in B, A groups (p<0.05) caused a positively significantly correlation between BNP peak level and leaman coronary score. There was increased trend of left ventricular end diastolic pressure (LVEDP) (p<0.05). Spearman correlation analysis showed significantly correlation between BNP peak levels and CK-MB, cTNI, LVEF, LVEDP levels. The linear regression equation between BNP peak levels and LVEFs, cTNI levels were Y=0.5466–0.00015X, Y=5.6314+0.0023X (p all <0.05).

Conclusion The higher the BNP peak levels, the higher the CK-MB, cTNI levels and the lower the LVEF in acute myocardial infarction patients. The between BNP peak levels had positive with CK-MB, cTNI peak concentrations and the degree of coronary artery disease, negative correlation-ship with LVEF.

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