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Basic science: Cardiovascular disease basic research
e0062 The relationship between two polymorphisms in CHRNA3 gene and nonsmall cell lung cancer evidence from a metaanalysis
  1. Niu Wenquan1,
  2. Gu Mingliang2,
  3. Zhang Xuezhi3,
  4. Guo Shujie1,
  5. Qi Yue4
  1. 1Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
  2. 2Chinese Academy of Sciences, Key Laboratory of Genome Science and Information Chinese Academy of Sciences, Chaoyang District, Beijing, China
  3. 3Clinical Laboratory of Biochemistry, Central Hospital of Shengli Oil Field, China Petrochemical Corporation, Dongying, China
  4. 4Capital Medical University, Affiliated Beijing Anzhen Hospital Beijing, Institute of Heart Lung & Blood Vessel Diseases, Anzhenli, Beijing, China

Abstract

Objective Lung cancer is the most common cause of cancer deaths worldwide; it is a complex disease that many genes involved (involves many genes) on chromosomes. Recently, several genome wide association studies have identified chromosomal region 15q24-25.1 as a hotspot for lung cancer risk. We therefore aimed to explore the association of CHRNA3 gene rs1051730 and rs8034191 polymorphisms of this region with lung cancer via meta-analysis.

Methods Random-effects model was performed irrespective of the between-study heterogeneity. Data and study quality were assessed in duplicate. Publication bias was evaluated using the fail-safe number.

Results Overall, five studies involving nine populations were identified for both rs1051730 (cases/controls: 7394/8784) and rs8034191 (9553/7953) polymorphisms. Genotype frequencies of two polymorphisms satisfied the Hardy–Weinberg law in controls. Presence of rs1051730 A allele was significantly associated with 32% increased risk of lung cancer (95% CI 1.25 to 1.39; p<0.00001). Contrastingly, rs8034191 C allele only conferred a marginal association yielding 18% increased risk (95% CI 0.99 to 1.42; p=0.07). Under assumption of dominant and recessive modes, risk magnitude was strengthened for rs1051730 with an increased risk of 39% (95% CI 1.30 to 1.48; p<0.00001) and 48% (95% CI 1.25 to 1.76; p<0.00001) for lung cancer, respectively. As for rs8034191, there was marginal or null association for the dominant (pooled OR=1.23; p=0.06) and recessive (pooled OR=1.26; p=0.15) modes. The fail-safe number at the level of 0.05 supported these significant associations.

Conclusions Our results demonstrated that the rs1051730 A allele was significantly associated with an increased lung cancer risk and the effect of rs8034191 polymorphism was moderate.

  • Polymorphism
  • CH3NA3 gene
  • lung cancer

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