Objective To investigate the changes in interleukin-8 (IL-8) and the relationship with the left ventricular aneurysm (LVA) and cardiac function in acute myocardial infarction (AMI) patients using left ventriculography (LVG).
Methods A total of 106 patients with primary anterior AMI accompanied LVA diagnosed by LVG were submitted to LVG after onset of AMI symptom and divided into LVA group and non-LVA group. Plasma IL-8 was measured. At the immediately after PCI and 6th month after AMI, the parameters of left ventricular end diastolic volume index (LVEDVI), left ventricular end systolic volume index (LVESVI), left ventricular ejection fraction (LVEF), wall motion score (WMS) and left ventricular end diastolic pressure (LVEDP) were measured by LVG. The main adverse cardiac events were recorded in 24th week after PCI.
Results There was no difference between the two groups in clinical characteristic, while the interval time of onset to reperfusion in LVA group was longer and the incidence of Killip 3 grade was higher than those in non-LVA group (p<0.05, respectively). The peak value of plasma IL-8 in LVA was significant higher and the peak time of plasma cTnI was much earlier than those in the non-LVA group (p<0.05, respectively). The peak values of plasma IL-8 in LVA group with LVEDP≥18 mm Hg were significant higher than that in non-LVA with LVEDP. The peak value of plasma IL-8 in LVA group with LVEDP<18 mm Hg were significant higher than that in non-LVA with LVEDP (p<0.05). At 6th month post-AMI, the value of LVEF, LVESVI, LVEDVI, WMS and LVEDP in non-LVA group were much better than those in LVA group. The values of LVEF, LVESVI, LVEDVI, WMS and LVEDP in non-LVA group at 6th month post-AMI were significantly improved as compared with those at the first time after PCI but the values of LVEDVI, WMS, LVEDP were improved in the LVA group. Within the 6th month follow-up, the incidences of angina post-AMI, heart failure of NYHA≥3 grade and mortality in LVA group were significantly higher than those in the non-LVA group (p<0.05, respectively).
Conclusions The value of plasma IL-8 is significantly increased and correlated closely with left ventricular remodelling status and haemodynamic change in patients with LVA after AMI. It is indicated that the over activity of immune inflammatory medium IL-8 involves in the process of LVA formation and has an important clinic significance in early diagnosis and appreciation of LVA post AMI.