Objective To investigate the level of plasma adiponectin (APN) in atrial fibrillation (AF) patients and clinical value.
Methods 1. 40 AF patients hospitalised in cardiology department in our hospital divided into two groups of paroxysmal and persistent (containing persistent and permanent AF) according AF guideline of ACC/AHA 2006. Control group comprised 15 patients admitted to hospital in Cardiology Department without AF. Plasma adiponectin level were measured and compared among the three groups. 2. All the patients fasting periphery venous flood acquired on the second morning, fasting plasma glucose (FPG), triglyeride (TG), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), creatinine (Cre) are tested by auto-biochemistry instrument, enzyme linked immunosorbent assay adopted. 3. Two-dimensional and Doppler echocardiography was performed using a Vivid 7 Dimension echo machine. Left ventricle end-diastolic diameter (LVEDD) and left atrial (LA) dimensions were standard M-mode measurements. Left ventricle ejection fraction (LVEF) was calculated using the modified Simpson's rule. 4. After centrifugation, 0.5 ml clear supernatant liquid of fasting periphery venous flood deserved in −80°C less than 5 months. APN concentration was measured by radio-immunity method. 5. Record each general state, including BMI, medicine taking, whether with or without hypertension, coronary heart disease and so on. All data are expressed as mean±SD. All analyses were performed using SPSS 17.0.
Results Adiponectin concentration in persistent AF was significantly higher than in control group and paroxymal group. Covariance analysis revealed that plasma adiponectin was also significantly associated with the presence of arterial fibrillation (p<0.05). Univariance analysis TG has influence on APN. Multiple linear regression show APN correlated negatively with TG, and APN in persistent AF group is higher than paroxymal AF group and controls.
Conclusion High plasma adiponectin levels are associated with the presence of persistent and permanent AF. Adiponectin concentration was correlated negatively with TG.
- Atrial fibrillation