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Related subjects: Biomarkers and laboratory testing for cardiovascular disease
e0677 Increased plasma NTerminal proBType natriuretic peptide in patients with hepatitis C virus infection
  1. Wenliang Che1,2,
  2. Wenling Liu3,
  3. Yidong Wei1,
  4. Yawei Xu1,
  5. Yisen Chen4,
  6. Yunli Huang4,
  7. Lei Li3,
  8. Jie Xiao5,
  9. Akira Matsumori6,
  10. Dayi Hu2,3
  1. 1Shanghai Tenth People?s Hospital, Tongji University, Shanghai, China
  2. 2Heart, Lung and Blood Vessel Center, Tongji University, Shanghai, China
  3. 3Heart Center, Peking University People?s Hospital, Beijing, China
  4. 4Beijing YouAn Hospital, Capital Medical University, Beijing, China
  5. 5Department of Cardiovascular Medicine, Beijing Tongren Hospital, Beijing, China
  6. 6Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan


Objectives Some studies suggested a possible role for hepatitis C virus (HCV) in the pathogenesis of cardiovascular diseases (CVD). N-terminal pro-brain natriuretic pepetide (NT-proBNP) has been proposed to be a neurohumoral marker of cardiovascular risk. Few prior studies have evaluated such levels in HCV infection. Accordingly, the objectives of the present study were to investigate circulating levels of NT-proBNP and their relevance in patients with HCV infection.

Methods We collected 131 HCV-infected patients and 131 age and gender matched healthy individuals from January 2006 to October 2007 in China. Demographics, clinical data were collected and circulating NT-proBNP was analysed, and 63 of patients were also consecutively evaluated with echocardiography.

Results The level of serum NT-proBNP was higher in HCV-infected patients compared with controls (76.62 fmol/ml vs 51.83 fmol/ml, p<0.001, geometric means), even in HCV-infected patients without cardiovascular abnormalities (CVD history and /or abnormalities of ECG) NT-proBNP also increased (63.46 fmol/ml vs 48.14 fmol/ml, p=0.015, geometric means). A NT-proBNP level in the highest tertile was associated with a higher risk of cardiovascular abnormalities, with OR of 17.91 (95% CI, 3.71 to 86.47). MVE/MVA, LVEF and FS were significantly lower among patients in the highest NT-proBNP tertile, whereas MVA was higher. In addition, compared with normal values of healthy Chinese population (39.35%±4.26%), the value of FS (36.76%±5.50%, p=0.015) was lower in patients whose serum NT-proBNP level was higher than median of controls (>56.17 fmol/ml, n=37).

Conclusions HCV infected individuals had higher NT-proBNP levels than age matched controls, which show a possible cardiac functional evidence for a pathogenic link between HCV and CVD. The finding is consistent with an increased incidence of HCV or HCV antibody described in some CVD patients.

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