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Related Subjects: Imaging in Cardiovascular Disease (Radiology, Ultrasonography, Nuclear Medicine, CT, MRI)
e0684 Right ventricular ejection fraction further decreases in heart transplanted HT patients when rejection occurs
  1. Chen Haiyan,
  2. Pan Cuizhen,
  3. Chen Changyu,
  4. Fang Xiaoyan,
  5. Chen Hao,
  6. Wang Chunsheng,
  7. Shu Xianhong
  1. Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases


Objective To investigate the shape and function of right ventricles in patients who received heart transplantation (HT) using single-beat real-time three-dimensional echocardiography (sRT-3DE).

Methods 60 healthy volunteers (40 male, mean age (43.69±14.81 years)) and 31 HT patients [27 male, mean age (40.10±14.67 years)] were enrolled consecutively as Normal controls and the HT group, respectively. All the participants received routine echocardiography as well as sRt-3DE by SIEMENS SC2000 to get parameters concerning morphology and systolic function of the right ventricle. All the HT patients received endomyocardial biopsy within 3 months before or after the echo exams and the HT group was further divided into the rejection group (HTr) and the non-rejection group (HTn) according to the endomyocardial biopsy results as well as the long term group (HTl) and the short term group (HTs) based on the post-operation length (cut point: 1 year), respectively. HTn was also divided into a long term group (HTnl) and a short term group (HTns) to rule out the influence of rejection on post-operation length.

Results 1. Right ventricular stroke volume and right ventricular ejection fraction (RVEF) were significantly different among the groups and the difference values progressively decreased. (Right ventricular stroke volume: Con vs HTn vs HTr was 56.18±23.72 vs 36.08±10.94 vs 26.22±9.84 (p<0.0001; RVEF: Con vs HTn vs HTr was 62.09±7.18 vs 51.04±7.58 vs 35.86±9.86, p<0.00001). 2. When taking the influence of rejection into consideration, none but RVEF proved to be a stable and sensitive indicator.

Conclusions sRt-3DE can quickly assess shape and systolic function of right ventricle. RVEF was the most stable and sensitive among all the RV-related and LV-related indicators and is a promising indicator in the clinic follow-up of HT patients.

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