Background Until now, the study of regional infarct and ischaemic myocardial function in patients with coronary atherosclerotic heart disease is still mainly focused on the abnormal wall motion, how the blood flow dynamics affected by the regional abnormal wall motion in CAD patients is remains unknown. The purposes of the present study are to investigate the blood flow dynamics adjacent to the regional ischaemic and infarct myocardial segments, to explore the correlation between the blood flow dynamics and wall motion and to explore sensitive indexes showing blood flow dynamics change caused by abnormal wall motion in CAD patients.
Methods 43 CAD patients were enrolled in our study. Velocity Vector Imaging technique was used to evaluate the wall motion so as to classify the myocardial segments as normal, ischaemic and infarct by systolic peak strain. Vector Flow Mapping (VFM) technique was performed to show the blood flow dynamics in the heart chamber. The blood flow volume heading towards or against the apex in different periods of a heart beat and the time to every peak flow were measured.
Results Compared to normal group, systole Q+ is higher (p<0.01), diastole Q+ is lower (p<0.01), T2 is shorter (p<0.01) in ischaemic group. Compared to non-infarct group, systole Q+ is higher (p<0.05), diastole Q+ is lower (p<0.01), T2 is shorter (p<0.05) in infarct group. There are correlations between indexes derived by VFM and Velocity Vector Imaging technique. Systole Q+ is a better index, when the cutoff value reaches 25.32 and 28.046; it has a high sensitivity and specificity for differentiating ischaemic and infarct segments.
Conclusion VFM is a novel noninvasive tool to assess the blood flow dynamics and can be used to evaluate the cardiac function.
- Vector flow mapping
- blood flow dynamics
- left ventricle
- abnormal wall motion
- velocity vector imaging
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