Objective To initial explore the clinical feasibility, accuracy and reproducibility of evaluation of left ventricular (LV) volume and ejection fraction (EF) by 4-Dimensional Auto Left Ventrcular Quantification (4D AUTO LVQ) in three-dimensional echocardiography.
Method Single heartbeat (SB) and multi-heartbeat (MB) mode three-dimensional echocardiography (3DE) examinations were performed in 20 volunteers, Left Ventricular end-diastolic volume (LVEDV), end-systolic volume (LVESV), and EF were measured by 4D AUTO LVQ. Meanwhile, LV volume and EF were also calculated by 2DE Simpson's method and M-modeTeichholtz method. The measurement value of LV volume and EF by 4D AUTO LVQ in SB and MB mode was separately compared with every measurement value by other methods.
Results 1. The values of LVEDV were statistically significant between M-mode method and other three methods (p<0.05). LVEDV measured by 4D AUTO LVQ in SB mode correlated and agreed well with MB mode (r=0.769). 2. There were significant difference in LVESV between M-mode method and other three methods. The correlation and agreement between SB and MB was well. (r=0.86). 3. Significant difference was found between 3DE and 2DE for EF, and also between 3DE and M-mode. Correlation between SB and MB3DE was poor (r=0.428), but the agreement was good. 4. There were no statistically significant difference between average store time of the 4D AUTO LVQ and 2DE Simpson's method. 5. Intra-observer variability of SB and MB 3DE for EF measured by 4D AUTO LVQ was 8.50% and 6.50%, and the inter-observer variability was 7.75% and 6.50%.
Conclusions 4D AUTO LVQ in three-dimensional echocardiography gives accurate, rapid and reproducible measurements of LV volumes and EF.