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Basic science: Cardiovascular disease basic research
e0067 Aspirin attenuates pulmonary arterial hypertension in rats by reducing plasma 5hydroxytryptamine level
  1. Shen Lan,
  2. Shen Jieyan,
  3. Bu Jun,
  4. Yuan Ancai
  1. Renji Hospital Shanghai

Abstract

Pulmonary arterial hypertension (PAH) is characterised by increasing pulmonary pressure, right ventricular failure, and death. The typical pathological changes include medial hypertrophy, intimal fibrosis and in situ thrombosis. 5-HT and other factors contributed to the development of pathologic lesions. Aspirin (ASA), the platelet aggregation inhibitor, inhibits 5-HT release from platelet. The aim of the current study was to determine the efficacy of aspirin in preventing or attenuating pulmonary hypertension. Sprague-Dawley (SD) rats injected with monocrotaline (MCT) at day 0 developed severe PAH at day 31. Rats were randomised to receive either vehicle or different dosages of aspirin (ASA 0.5 mg/kg/d, ASA 1 mg/kg/d, ASA 2 mg/kg/d, ASA 4 mg/kg/d). Aspirin suppressed PAH and increased survival rate compared with the placebo group (84% vs 60%, p<0.05). Aspirin treatment also reduced right ventricular hypertrophy and pulmonary arterioles proliferation. Plasma 5-HT measured by High Performance Liquid Chromatographic (HPLC) was decreased in aspirin treated PAH model. The degree of 5-HT reduction was associated with systolic pulmonary arterial pressure, right ventricular hypertrophy and wall thickness of pulmonary arterioles in rats. These results showed ASA treatment has effectively attenuated MCT-induced pulmonary hypertension, right ventricular hypertrophy and occlusion of pulmonary artery. The effects of ASA may be associated with reduction of 5-HT.

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