Background Both Low plasma HDL cholesterol (HDL-C) and inflammatory responses are associated with an increased risk of coronary artery disease (CAD). Serum amyloid A protein (SAA) is not only an inflammatory factor but also an apolipoprotein that can replace apolipoprotein A1 (apoA1) as the major apolipoprotein of HDL. However, the relationship between genetic polymorphisms of SAA and CAD remains unclear.
Methods 4 Single Nucleotide Polymorphisms (SNPs) (rs12218, rs1059559, rs2229338, and rs2468844) of SAA1 and SAA2 gene were genotyped in 1580 CAD patients and 1914 age- and sex-matched controls by the use of PCR-restriction fragment length polymorphism (PCR-RFLP) analysis.
Results The CC genotype and C allele of rs12218 and the GG genotype and G allele of rs2468844 were more common in the CAD patients than in the control subjects, respectively (all p<0.001). After adjusted for diabetes mellitus, hypertension, smoking, drinking and lipid disorders by use of logistic regression, the SNPs rs12218 (OR=5.906, 95% CI 2.877 to 12.124, p<0.001) and rs2468844 (OR=4.102, 95% CI 2.018 to 8.129, p<0.001) still differed significantly between the CAD patients and control subjects.
Conclusion These data suggest that genetic polymorphisms of SAA1/2 gene significantly increased the risk of CAD in a Chinese Han population.