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Basic science: Cardiovascular disease basic research
e0103 The HindIII polymorphism in the lipoprotein lipase gene predicts type 2 diabetes risk among Chinese adults
  1. Qi Yue1,
  2. Liu Jing2,
  3. Wang Wei2,
  4. Wang Miao2,
  5. Sun Jiayi2,
  6. Liu Jun2,
  7. Li Yan2,
  8. Qin Lanping2,
  9. Wu Zhaosu2,
  10. Zhao Dong2
  1. 1Capital Medical University Beijing Anzhen Hospital Beijing Institute of Heart Lung And Blood Vessel Diseases Beijing China
  2. 2Capital Medical University Beijing Anzhen Hospital Beijing Institute of Heart Lung And Blood Vessel Diseases Beijing China

Abstract

Objective To explore whether the HindIII polymorphism in the lipoprotein lipase (LPL) gene has a potential role in susceptibility to type 2 diabetes, and whether this relation is influenced by regulating LPL or other risk factors.

Research design and methods Overall, 654 Han Chinese adults were recruited from a community-based cross-sectional study. Genotyping was performed using the PCR-RFLP technique. Pre-heparin LPL (PrLPL) and other metabolic variables were measured using standard methods.

Results Individuals with the HindIII H–/H– genotype tended to have higher PrLPL and lower triglyceride (TG) levels but an unexpected higher prevalence of type 2 diabetes compared with carriers with the H+H+ genotype. The association between the H–/H– genotype and diabetes risk remained unchanged across all subgroups of diabetes-related risk factors and PrLPL. In an additive model, the H–/H– genotype conferred 178% increased risk [OR:2.78; 95% CI 1.04 to 7.47] for diabetes after controlling for age and sex. The strength of this association increased further after adjusting for other traditional risk factors, and for PrLPL (OR=4.06; 95% CI= 1.35 to 12.23). Furthermore, the H–/H– genotype was also associated with an increased risk of dysglycemia defined as insulin resistance plus diabetes.

Conclusions This study revealed that Chinese adults with the LPL gene HindIII H–/H– genotype had a significantly increased risk of type 2 diabetes compared with individuals with other genotypes, even if they had favourable lipid profiles.

  • HindIII polymorphism
  • preheparin lipoprotein lipase
  • type 2 diabetes
  • risk

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