Objective The aim of this study was to investigate whether myeloperoxidase gene polymorphism and its plasma levels were associated with risk of coronary artery disease (CAD) in Chinese population.
Methods A case-control study was conducted in Fujian provincial hosipital, 157 patients with established CAD (cases) and 78 individuals without angiographically significant CAD (controls) were enrolled. Blood samples were collected to identify the MPO polymorphism and its plasma levels.
Results Genotypes were determined in all individuals. The frequencies of three genotypes were significantly different in both group (p<0.05). Plasma MPO levels were significantly greater in patients with CAD than in controls (332.05±167.56 pg/ml vs 277.81±142.68 pg/ml, p<0.05). In the case group, 7(4.5%) were homozygous for AA, 101(64.3%) for GG and 49(31.2%) were heterozygous. Mean MPO plasma levels were 200.10±31.47 pg/ml for AA, 297.43±125.28 pg/ml for AG and 367.66±177.14 pg/ml for GG genotypes. In the case group, the MPO levels with GG were significantly higher than that in individuals with GA(p<0.05) and AA(p<0.05), but with no difference between GA and AA genotype (p>0.05). Plasma MPO levels correlated with its genotype.
Conclusion We found association between MPO polymerase and its plasma levels with CAD risk in Chinese population. These findings provide new sights for atherosclerosis diagnosis and risk assessment.